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No cost and conjugated noroxycodone, cost-free and conjugated oxycodone, and oxymorphone are excreted in human urine subsequent one oral dose of oxycodone. The foremost circulating metabolite is noroxycodone with an AUC ratio of 0.six relative to that of oxycodone. Oxymorphone is existing from the plasma only in very low concentrations. The analges